SHORT COMMUNICATION Prevalence of mutations and determinants of genotypic resistance to etravirine (TMC125) in a large Italian resistance database (ARCA)*w
نویسندگان
چکیده
P Di Vincenzo, S Rusconi, F Adorni, P Vitiello, F Maggiolo, D Francisci, A Di Biagio, L Monno, A Antinori, E Boeri, G Punzi, C-F Perno, A Callegaro, B Bruzzone and M Zazzi on behalf of the Antiretroviral Resistance Cohort Analysis (ARCA) Collaborative Group Sezione Malattie Infettive e Immunopatologia, Dipartimento di Scienze Cliniche ‘Luigi Sacco’, Universita’ degli Studi, Milan, Italy, ITB-CNR, Segrate (MI), Italy, Ospedali Riuniti, Bergamo, Italy, Perugia Hospital, Perugia, Italy, San Martino Hospital, Genova, Italy, University of Bari, Bari, Italy, INMI ‘Lazzaro Spallanzani’ Hospital, Rome, Italy, HSR Scientific Institute, Milan, Italy and University of Siena, Siena, Italy
منابع مشابه
Selection of nonnucleoside reverse transcriptase inhibitor-associated mutations in HIV-1 subtype C: evidence of etravirine cross-resistance.
Prevalence of etravirine genotypic resistance was assessed among 92 HIV-1C-infected patients failing nevirapine and efavirenz-based regimens from a cohort of 552 Indian patients. Overall, prevalence of etravirine cross-resistance identified using the Tibotec Weighted Score was 41% (31.5% intermediately-resistant and 9.8% fully-resistant). The most frequently described nonnucleoside reverse tran...
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The results of computer simulations of the binding of etravirine (TMC125) and rilpivirine (TMC278) to HIV reverse transcriptase are reported. It is confirmed that consistent binding free energy estimates are obtained with or without the application of torsional restraints when the free energies of imposing the restraints are taken into account. The restraints have a smaller influence on the the...
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